Tox Path Specialists is an industry leader in the field of neuropathology, specializing in studies with direct delivery administrations such as intrathecal, intracerebroventricular, and more. Dr. Butt and the other staff pathologists at TPS have years of experience in evaluating the complex effects of direct delivery administration on the nervous system, in addition to general toxicology evaluations.
Before your study starts, our pathologists can offer advice about vital control groups, appropriate group sizes, necessary experimental time points, tissue sampling strategies, optimal tissue fixation and processing, and important histochemical stains and immunohistochemical labels.
TPS is a fully GLP-compliant laboratory and can provide various reporting formats to meet your needs. Using our own internally-developed software applications, TPS is also able to provide several SEND data sets using the most up-to-date controlled terminologies, cutting down the amount of work you have to perform when submitting data to regulatory agencies.
Stereology and Morphometry
In addition to the company’s capabilities listed above, Tox Path Specialists is also a fully capable stereology and morphometry laboratory. These quantitative assessments are used to supplement the neuropathology investigations in order to form a comprehensive interpretation of studies. Stereology/Morphometry investigations performed at Tox Path Specialists include counting and measuring cells, determining region of interest area/volume, intraepidermal nerve fiber density, and more.
Intraepidermal Nerve Fiber Density
In order to determine potential changes in distal sensory nerves, Intraepidermal Nerve Fiber (IENF) Density assessments may augment findings made during a general morphologic evaluation of peripheral neuropathies. IENF density investigations can be quantitative (where nerve fibers crossing the dermal-epidermal junction are actually counted) or qualitative (where an assessment of relative changes in density are made).
Peer Reviews and Pathology Working Groups
Peer review and/or pathology working groups can be an important component of study interpretation, offering additional opinions on tissue changes. TPS pathologists can review the results of studies interpreted elsewhere and provide internal reviews of studies read in-house, all in an attempt to ensure that you are receiving the most accurate interpretations of you studies.